Monday, December 6, 2010

1. A dangerous good is:

Sunday, October 31, 2010

HAM-A Scale

Hamilton Rating Scale for Anxiety
Gold Standard - measure for Anxiety - /56
Severity - 0 to 4 - total score for 14 items is 56
Assesses psychic and somatic anxiety

MINI Scale

MINI International Neuropsychiatric Interview (MINI)

  1. Validated, structured interview
  2. Assesses the major Axis I disorders in DSM-IV and ICD-10
  3. Assesses current and some lifetime diagnoses
  1. Major Depressive Episodes
  2. Suicidality
  3. Manic Episode
  4. Panic Disorder
  5. Agoraphobia
  6. Social Phobia & Social Anxiety Disorder
  7. Obsessive Compulsive Disorder
  8. Posttraumatic Stress Disorder
  9. Alcohol Dependance and Abuse
  10. Substance Dependence and Abuse (non Alcohol)
  11. Psychotic Disorders
  12. Anorexia Nervosa
  13. Bulimia Nervosa
  14. Generalized Anxiety Disorder
  15. Medical, Organic, Drug Cause Ruled out
  16. Antisocial Personality Disorder

Healthcare Resource Utilisation and Work Absence - HRUWA

Clinician administrable
- to capture information about the costs of illness

  1. Healthcare utlilization
  2. Loss or work productivity
Define contact - telephone call, appointment or visit with someone
  1. Hospital admission
  2. Emergency Room 
  3. General Practitioner
  4. Consultant / Specalist
Diagnostic procedures
  1. Physical examination
  2. X-ray/CT
  3. Neurophysiology tests
  4. Laboratory tests
Missed work
  1. Subject
  2. Spouse and family member or friend

Discontinuation Emergent Signs and Symptoms (DESS)

43 Items
The DESS is a 43 item checklist of symptoms associated with discontinuation of antidepressant agents. It is administered during the Post Treatment phase and should be completed by the subject.

C-CASA and C-SSRS in CNS Clinical Trials

Suicide Scales in Depression

Antidepressant Treatment History Form - ATHF

Used to assist clinicians in defining the adequacy and response to previous antidepressant treatments:
Standardized across study comparison
Rank information about antidepressant treatment adequacy
Time frame:

  1. Both current and past episodes captured
  2. 2 months euthymia required to count as separate episodes
  3. Adequate medication trial at >4weeks
  4. Medication start and stop dates must be obtained
  5. ECT start and stop dates must be obtained
Include all medical records
Detailed as possible
  1. start and stop dates
  2. reason for changes
  3. daily doses
  4. clinical outcome of medication 
Include all psychotropic medications taken to putatively treat the condition:
Consider Antidepressant Resistance Rating (ARR) (3 or higher is adequate)
Subtract one if patient discontinued due to poor tolerability, noncompliance
ECT is not counted as a combination